Project updates

Update 1

2016 was a busy year for the FADH grant. Professor Devaney visited the laboratory of Professor Utpal Tatu in Bangalore, India in February, where she presented a seminar on the work carried out to date in the Glasgow laboratories and discussed the results of ongoing experiments. While in Bangalore she also took part in a meeting to discuss antimicrobial resistance in veterinary infectious disease. The meeting was held under the auspices of the UK Department of Business, Innovation and Skills (BIS), with the aim of supporting delivery of the global strategy on AMR. It was organized by Professor Utpal Tatu from the Indian Institute of Science, Bangalore, aided by Swati Saxena, the senior science and innovation adviser of the British High Commission in New Delhi. There were five delegates from the UK and several participants from India, covering a wide range of areas. The Bangalore meeting covered many interesting areas related to AMR, including food hygiene and AMR, antimicrobial stewardship, vaccine production as an alternative to drug therapy, indigenous plant-based therapies, and epidemiological factors determining the spread of resistant microbes.

On the Saturday, the highlight of the meeting was a field trip to a ‘Camp’ in the countryside a couple of hours outside Bangalore, which Prof Tatu has been involved in establishing. Local farmers bring their livestock for diagnosis and treatment by veterinarians. Infections with both Theileria and Babesia are seen.

Although most of the animals seen at the camp were cattle, we also saw many flocks of sheep and goats in the countryside around Bangalore

Given that a recent review in the Lancet Infectious Diseases (Czaplewski, et al.) suggested that the worldwide cost of dealing with the issue of AMR would fall somewhere between the £6 billion of the Large Hadron Collider and the £96 billion of the International Space Station, it is abundantly clear that no one country can tackle the problem in isolation. This was an excellent scoping meeting, which hopefully will lead to further collaborations between UK and India on this important topic.

Update 2

In June of 2016, Dr Vicky Gillan, the post-doctoral research associate on the project in Glasgow attended the 5th Annual Meeting of the International Society for Extracellular Vesicles in Rotterdam, the Netherlands. She presented a poster there on here recent characterisation of small extracellular vesicles produced by Theileria infected cells and their possible role in the pathogenesis of infection.

Update 3

In October 2016 we submitted our first joint publication between the Glasgow and Indian laboratories, which describes the characterisation of the different isoforms of Hsp90 in Theileria annulata. We were delighted to see it in press shortly afterwards. This is an open access publication and can be accessed here.